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当前位置: 首页 > 产品中心 > Nuclear Receptors > Excellgen/Retinoid X Receptor alpha, RXRA/RP-141/10,000 U

Excellgen/Retinoid X Receptor alpha, RXRA/RP-141/10,000 U

Excellgen/Retinoid X Receptor alpha, RXRA/RP-141/10,000 U
  • Excellgen/Retinoid X Receptor alpha, RXRA/RP-141/10,000 U
商品介绍
ProductNameRetinoidXReceptoralpha,RXRA
Size10,000U
DescriptionNuclearreceptorsformthelargestknownfamilyoftranscriptionfactorsandhaveacrucialroleinnearlyallaspectsofvertebratedevelopmentandadultphysiologybytransducingtheeffectsofhormonesintotranscriptionalresponses(1).Thefamilyisdefinedbytwodomains:(a)thecentral,highlyconserved,DNA-bindingdomain(DBD)ofapprox.66aminoacids,and(b)theC-terminal,structurallyconserved,ligand-bindingdomain(LBD)ofapprox.250aminoacids(2,3).InadditiontobindingtoDNAandactivatingtranscriptioninresponseto9-cisretinoicacid,RXRformsheterodimerswiththereceptorsforthyroidhormone(TR),retinoicacid(RAR),vitaminD(VDR),prostanoids(PPAR),andnumerousorphanreceptors(4).RXRactsasbothactivatorandrepressoroftranscription(5).Intheabsenceofhormone,RXR(homo-orheterodimer)interactswithSMRT(silencingmediatorforretinoidandthyroidhormonereceptors)andN-CoR(nuclearreceptorcorepressor)andrepressestranscriptionthroughrecruitmentofhistonedeacetylases(6,7).Inthepresenceofhormone,RXRinteractswithanumberofactivatorsincludingtheSRC-1family(8),CBP/p300(9),pCAF(10)andtheTRAPcomplex(11)totargetchromatinacetylationactivateoftranscription(12)
Applications
  • reconstitutedinvitrotranscriptionassays
  • protein-proteininteractionsassays
SourceE.coli
FusionTag6XHis
PurificationMethodFPLC
UnitDefinition(Activity)1unitequalsto1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;100unitsaresufficientforprotein-proteininteractionassays
Purity

~95%asdeterminedbySDS-PAGE

GeneID6256
Accession#NM_002957
GeneName

retinoidXreceptor,alpha

GeneSymbolRXRA
GeneSynonymsNR2B1
MW53.3kDa
ProteinSequenceMDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
StorageBuffer20mMTris-HCl,pH8.0,250mMNaCl,1mMDTT,50%Glycerol
Storage-20to-80°C.
Shipping4°Cordryice
References1.Mangelsdorf,D.J.,etal.,(1995)Cell83,835–839
2.Glass,C.K.(1994)Endocrinol.Rev.15,391–407
3.Moras,D.,etal.,(1998)Curr.Opin.CellBiol.10,384-391
4.KliewerS.A.,etal.,(1992)Nature355,446–449
5.GlassC.K.,etal.,(1989)Cell59,697-708
6.NagyL.,etal.,(1997)Cell89,373-380
7.Heinzel,T.,etal.,(1997)Nature387,43-48
8.Onate,S.A.,etal.,(1995)Science270,1354-1357
9.Kamei,Y.,etal.,(1996)Cell85,403-414
10.Blanco,J.C.,etal.,(1998)GenesDev.12,1638-1651
11.Fondell,J.D.,etal.,(1996)Proc.Natl.Acad.Sci.USA93,8329-8333
12.Wolffe,A.,etal.,(1997)GenesCells2,291-302
品牌介绍

ExcellGene is a privately owned and science-driven company, founded in 2001 by Prof. Florian M. Wurm and led since 2017 by Dr. Maria João Wurm, CEO. We are based in Monthey, Switzerland.
F. Wurm is a former manager and scientist at Genentech Inc. in South San Francisco and was among the pioneering scientists to generate manufacturing processes for the first pharmaceutical proteins made in CHO cells.
Maria J. De Jesus, now Maria J. Wurm, co-founding scientist of ExcellGene, invented and developed several breakthrough technologies as Senior Scientist at the Swiss Federal Institute of Technology (EPFL) in Lausanne. These inventions  have had profound effects on cell line development, and some have attained global application in early R&D work towards clinical manufacturing of biologics.
ExcellGene caters to clients worldwide and specializes in challenging protein expression goals.

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